Enhances insulin sensitivity and glucose regulation.
Supports efficient energy use.
Strengthens cellular resilience.
Slows down aging processes.
Anti-inflammatory properties.
Helps regulate body weight.
Overview MOTS-C is a mitochondria-derived peptide encoded within the mitochondrial genome — making it one of the most unique and exciting compounds in longevity research. It acts as a metabolic regulator, improving insulin sensitivity, enhancing fat oxidation, and supporting the body’s ability to maintain metabolic homeostasis under stress. Research suggests it may be one of the key molecular signals behind the metabolic benefits of exercise.
Mechanism of Action MOTS-C works by activating AMPK (AMP-activated protein kinase), the master metabolic switch of the cell. This activation promotes glucose uptake, enhances fatty acid oxidation, and reduces insulin resistance. MOTS-C also translocates to the nucleus in response to metabolic stress, where it regulates gene expression related to antioxidant defense and mitochondrial function.
Research Applications Research on MOTS-C has explored its role in improving insulin sensitivity and metabolic flexibility, reducing age-related weight gain, enhancing physical performance and endurance, and extending healthy lifespan in animal models. It has also been studied in the context of type 2 diabetes prevention, obesity, and sarcopenia (age-related muscle loss).
Reconstitution & Storage MOTS-C is supplied as a lyophilized powder. Reconstitute by adding bacteriostatic water slowly along the inner wall of the vial. Store unreconstituted vials refrigerated. Once reconstituted, keep refrigerated.
MOTS-C 20mg [Metabolic efficiency + longevity] comes as a lyophilized powder and must be reconstituted before use.
You’ll need bacteriostatic water and insulin syringes,
both available for purchase as add-ons below.
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Age & Research Use Confirmation
By accessing this website and purchasing from Greyline Peptides, you confirm and agree that:
All products sold are intended strictly for laboratory research purposes only
Products are not intended for human or veterinary use
Products are not drugs, supplements, or therapeutic agents
Products have not been approved by Health Canada for medical use
You are purchasing as a qualified researcher, institution, or laboratory entity, or on behalf of one
You are 19 years of age or older.
Any dosing reference materials provided are compiled from publicly available research literature and are intended solely to support laboratory research protocols. They do not constitute medical advice, prescriptions, or recommendations for human use.
By proceeding, you acknowledge that you assume full responsibility for the lawful handling and use of these research materials in accordance with all applicable federal, provincial, and territorial laws and regulations.