Overview LL-37 is the only member of the cathelicidin family of antimicrobial peptides found in humans, making it one of the most important components of the innate immune system. It is produced naturally by immune cells, epithelial cells, and skin cells in response to infection and inflammation. Research on LL-37 has revealed a remarkably broad spectrum of biological activity — from direct antimicrobial action to wound healing, immune modulation, and even anti-cancer properties.
Mechanism of Action LL-37 exerts its antimicrobial effects by disrupting the cell membranes of bacteria, fungi, and enveloped viruses through electrostatic interaction with negatively charged microbial membranes. Beyond direct killing, it acts as an immune modulator by stimulating the recruitment of immune cells to sites of infection, promoting angiogenesis, and activating toll-like receptor signaling pathways. It also promotes epithelial cell migration and proliferation, directly contributing to wound closure.
Research Applications Research on LL-37 has focused on its broad-spectrum antimicrobial activity against drug-resistant bacteria (including MRSA), antiviral properties, wound healing acceleration, anti-biofilm activity, and immune system modulation. It has also been studied in the context of cancer research, where it has demonstrated selective cytotoxicity against certain tumor cell lines, and in inflammatory skin conditions such as psoriasis and rosacea.
Reconstitution & Storage LL-37 is supplied as a lyophilized powder. Reconstitute by adding bacteriostatic water slowly along the inner wall of the vial. Store unreconstituted vials away from direct light. Once reconstituted, keep refrigerated.
LL-37 (5mg) — Antibiotic & Infection-Fighting Peptide comes as a lyophilized powder and must be reconstituted before use.
You’ll need bacteriostatic water and insulin syringes,
both available for purchase as add-ons below.
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By accessing this website and purchasing from Greyline Peptides, you confirm and agree that:
All products sold are intended strictly for laboratory research purposes only
Products are not intended for human or veterinary use
Products are not drugs, supplements, or therapeutic agents
Products have not been approved by Health Canada for medical use
You are purchasing as a qualified researcher, institution, or laboratory entity, or on behalf of one
You are 19 years of age or older.
Any dosing reference materials provided are compiled from publicly available research literature and are intended solely to support laboratory research protocols. They do not constitute medical advice, prescriptions, or recommendations for human use.
By proceeding, you acknowledge that you assume full responsibility for the lawful handling and use of these research materials in accordance with all applicable federal, provincial, and territorial laws and regulations.
